EPHB2 and cancer: For example, in CRC, Fusobacterium nucleatum can invade cancer cells and promote pre-ephrin type-B receptor 2 (EPHB2) reverse splicing into hsa_circ_0004085, a circular RNA for which its expression is negatively correlated with patients’ response to the chemotherapeutic drugs oxaliplatin and 5-fluorouracil (5-FU), through the regulation of heterogeneous nuclear ribonucleoprotein (hnRNP) L [230].