To further support the importance of IGF2 in HD via GEO database, we surveyed the other two datasets, GSE97100 using HD patient iPSC-derived brain microvascular endothelial cells(Supplementary Fig. 1A and 1B) [31] and GSE74201 using HD patient iPSC-derived differentiated neural stem cells(Supplementary Fig. 1C and 1D) [32, 33]. The gene discussed is IGF2; the disease is Huntington disease.