Additionally, Homo sapiens APN + AdipoR1 + AdipoR2 + IBD targets are associated with hepatocyte nuclear factor-3beta gene (HNF3B), glucagon, glucocorticoid receptor (REG GR), activator protein 1 transcription factor (AP1) and histone deacetylase (HDAC) class I pathway, lipid and atherosclerosis, type II diabetes mellitus (Fig. 5G), while that of mouse musculus influence glycerolipid, starch, sucrose and fatty acid metabolism, p53 and apelin signaling pathway, insulin secrenion, adherens junction (Fig. 5H). Here, FOXA2 is linked to type 2 diabetes mellitus.