APN potentially interfere with nutrition and energy homeostasis through AdipoR2 without AdipoR1, thus affecting the peripheral phylogeny of IBD. Top 20 GO enrichment of both Homo sapiens (Fig. 5E) and mouse musculus (Fig. 5F) intersection targets of APN + AdipoR2 + IBD with APN RS ≥ 10 (Table S3) excepting APN + AdipoR1 + AdipoR2 + IBD play a crucial part in lipid and chemical homeostasis, negative regulation of multicellular organismal process, response to hormone and organonitrogen compound. This evidence concerns the gene ADIPOR2 and inflammatory bowel disease.