APN-AdipoR1 axis aggrandizes the expression of pro-inflammatory factors and neutrophil chemokines, and then recruits neutrophils into colon to exacerbating the deterioration of IBD [4], which is also a common IBD phenotype in mice with short-term AdipoR1 deficiency [21] and AdipoR1 overexpression [4]. The gene discussed is ANPEP; the disease is inflammatory bowel disease.