APN regulates CD through AdipoR1/2-metabolism process and UC through AdipoR1-inflammation axis or AdipoR2-fibrosis process. Intersection targets of APN + AdipoR1 + AdipoR2 + IBD are mainly based on metabolic factors INS, GAPDH, PPARG, AKT1, PPARA, PPARA in Homo sapiens and AKT1, PPARG, PPARA, PPARGC1α, SIRT1 in Mouse musculus, where less are inflammatory factors including TNF and IL6 in Homo sapiens or Mouse musculus (Fig. 4A and F-G). The gene discussed is IL6; the disease is Cowden disease.