AdipoR1 and AdipoR2 may be complementary in IBD. Although the probability of interaction between APN and IL-6, TNF-α, INS, PPARG, PPARA is lower than that of AdipoR1/2, their interaction areas are larger (Fig. 6K1-M3, N2-R2) and ΔiG is lower than that of AdipoR1/2 (Fig. 6K1-M3, N3-R3). Here, INS is linked to inflammatory bowel disease.