Mechanism of APN in IBD through AdipoR1 without AdipoR2 may be attributed to neurologic and peripheral immune regulation. Top 20 GO enrichment of either Homo sapiens (Fig. 5C) or mouse musculus (Fig. 5D) intersection targets of APN + AdipoR1 + IBD with APN RS ≥ 10 (Table S2) excepting APN + AdipoR1 + AdipoR2 + IBD plays a key role on positive regulation of leukocyte, odontoblast, lymphocyte differentiation and activation, multicellular organismal development, hemopoiesis, negative regulation of immune system process. Here, ADIPOR1 is linked to inflammatory bowel disease.