Most cross-targets of APN + AdipoR1 + IBD are inflammatory factors including IL6, FOXP3, CXCL10, CX CR4, IL2RA, CRP, NLRP3 in Homo sapiens and CSF2, CXCL5, IL2RA, CRP, NLRP3, CXCR4, NOD2 in Mouse musculus (Fig. 4A and H-I). Here, NLRP3 is linked to inflammatory bowel disease.