APN adjusts PI3K-Akt signaling pathway through AdipoR2 instead of AdipoR1 to influence IBD. Except for the intersection with AdipoR2, the intersection target enrichment of Homo sapiens (Fig. 5I) and mouse musculus (Fig. 5J) APN + AdipoR1 + IBD is only related to pathways in cancer and cytokine-cytokine receptor interaction. This evidence concerns the gene ANPEP and inflammatory bowel disease.