IL18 and inflammatory bowel disease: Homo sapiens APN + AdipoR1 + IBD targets also regulate T cell, neuroepithelial cell, glial cell differentiation and activation, cell adhesion, connective tissue development (Fig. 5C), while mouse musculus APN + AdipoR1 + IBD targets extra affect interleukin-18 production, cellular response to endogenous stimulus, localization and negative regulation of myeloid leukocyte differentiation (Fig. 5D).