The APN + AdipoR1 + AdipoR2 + IBD target intersections with the highest confidence are more likely to interact with AdipoR1/2 than with APN, including IL-6, TNF-α, INS, PPARG, PPARA, CRP, AMPK, PI3Kα and AKT. The gene discussed is INS; the disease is inflammatory bowel disease.