Interestingly, gene silencing of P2Y12 and P2Y13 receptors both increased the density of the P2Y1-receptor in Pm BM-MSC, but this effect was particularly evident 7 days after cells infection with the lenti-shRNA designed to target the P2Y13 receptor gene transcript and, thus, contributing to decrease the P2Y13/P2Y1 density ratio. The gene discussed is P2RY1; the disease is infection.