Likewise, P2Y1 and P2Y11 receptors can also associate when co-transfected to HEK293 and 1321N1 astrocytoma cells; this interplay promotes agonist-induced internalization of the P2Y11 receptor, which on its own does not undergo endocytosis [64]. This evidence concerns the gene P2RY1 and astrocytoma (excluding glioblastoma).