It is important to note that a previous study has shown association of GRN variants with Gaucher disease [57], demonstrating a genetic interaction between GRN and GBA1. Consistent with the human genetic study, PGRN deficiency has been shown to exacerbate Gaucher disease-associated phenotypes of Gba1D409V/D409V knockin mice [214]. This evidence concerns the gene GBA1 and Gaucher disease.