Multiple SNPs near and in the TMEM106B gene, including the SNPs associated with neurodegenerative diseases described above, such as rs1990622, rs6966915, and rs1020004, are in strong linkage disequilibrium (LD), constituting two common TMEM106B haplotypes, one associated with increased disease risk, and the other with a protective effect [10, 78] (Fig. 2a). This evidence concerns the gene TMEM106B and neurodegenerative disease.