In addition to AD and PD/LBD, GRN variation has also been implicated in Gaucher disease [57], FTLD-TDP and/or motor neuron disease with C9orf72 repeat expansions [58], ALS [59], and limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) [60]. Here, GRN is linked to Alzheimer disease.