However, taking into account the relevant literature data, it can be concluded that the role of P2X7 in sepsis, the anti-inflammatory feature of P2X7 antagonists and the hypo-inflammatory nature of neonatal immune responses make P2X7 a potential target for neonatal sepsis as an adjunct to antibiotic therapy, provided that pathogen elimination as a result of antibiotic treatment is adequately supported by laboratory tests. This evidence concerns the gene P2RX7 and Sepsis.