Both LPS and poly(I:C) treatment induced the expression and activation of NLRP3 and IL-1β in the brain of offspring rats showing schizophrenia-like behaviours [194] In vitro studies show higher baseline and LPS-induced Caspase-1, NLRP3, and secreted IL-1β levels in PBMCs from individuals with ASD [195]. Here, NLRP3 is linked to schizophrenia.