At the Canadian Cardiovascular Society guideline threshold designating HF as “very likely” (ie, BNP of 400 ng/L or NT-proBNP of 900 ng/L for ages 50-75 years), the absolute adjusted 1-year all-cause mortality was 4.9% and 3.3% higher, respectively, in males compared to females.3 This evidence concerns the gene NPPB and hydrops fetalis.