RAB5A and ductal breast carcinoma in situ: Qualitatively, the shape of control spheroids at 3 and 5h resembled the one of polymer melts, comprised of a spherical cap, a foot, and a precursor film region, thus highlighting the effect of viscosity during DCIS spheroid spreading.[13] The dynamical contact angle θD, measured at the interface between the core and the solid substrate—to reflect the balance of interfacial tensions for the bulk aggregate[13, 22]—qualitatively decreased faster upon RAB5A expression, as compared to the control condition.