The early stage is characterized by high viral loads and infiltration of proinflammatory macrophages with a strong type I interferon (IFN) response, while the later stage involves tissue repair, viral clearance, and a diminished IFN response.[24] In this study, we applied CosMx spatial transcriptomics to comprehensively profile immune cell dynamics and epithelial cell injury in COVID‐19 lung tissues. This evidence concerns the gene IFNA1 and COVID-19.