To investigate the role of MGE-derived GABAergic neurons in myoclonus dystonia, neurons were differentiated from two patient-derived SGCE mutation-positive hiPSC lines (Patients 1 and 2) and a single CRISPR/Cas9-edited SGCE knockout iCas9 hESC and their matched isogenic wild-type control lines (Fig. 1A). The gene discussed is SGCE; the disease is myoclonus-dystonia syndrome.