In order to discover the co-occurrence of the CTNNB1 missense mutations, which are associated with the promotion of carcinogenic features [13], and RSPO2 alterations, we compared the frequency of RSPO2 amplifications with CTNNB1 missense mutations across 22 primary and metastatic PC patient cohorts from cBioPortal. The gene discussed is CTNNB1; the disease is pachyonychia congenita.