In order to discover the co-occurrence of the CTNNB1 missense mutations, which are associated with the promotion of carcinogenic features [13], and RSPO2 alterations, we compared the frequency of RSPO2 amplifications with CTNNB1 missense mutations across 22 primary and metastatic PC patient cohorts from cBioPortal. Here, RSPO2 is linked to pachyonychia congenita.