Moreover, while previous research has shown that fluvoxamine– but not sertraline, an SSRI with Sig-1R antagonistic properties– ameliorates PCP-induced cognitive deficits in mice, the current study did not examine whether sertraline has similar or differing effects in the ketamine model, which could help clarify the role of Sig-1R modulation among SSRIs. This evidence concerns the gene SIGMAR1 and Cognitive impairment.