This association plays a key role in a range of normal neuronal activities, including synaptic plasticity, learning, and memory, while direct inhibition nNOS, PSD-95 or NMDARs can have severe side effects, contributing in the development of brain pathologies such as schizophrenia (Coley and Gao 2018; Gu and Zhu 2020). This evidence concerns the gene NOS1 and schizophrenia.