A decrease in frontal cortical nNOS and PSD-95 in schizophrenic patients causes a severe glutamatergic attenuation within the brain with consequent overall decrease in the prefrontal cortical neuronal activity inducing schizophrenic-like symptoms like cognitive deficits and working memory impairments (Nasyrova et al. 2015; Coley and Gao 2019). Here, DLG4 is linked to Cognitive impairment.