In fact, mouse models that develop Aβ plaques but do not overexpress tau require the introduction of misfolded AD-related tau seeds to exhibit the three hallmark forms of tau pathology seen in Alzheimer’s disease: tau-positive dystrophic neurites surrounding Aβ plaques (NP tau), neuropil threads, and neurofibrillary tangles (NFTs). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.