Treatment of BxPC-3 human pancreatic cancer cells with different concentrations of juglone reduced the expression of MMP-2 and -9 genes in a dose-dependent manner, and VEGF induced a significant reduction in the level of expression of Phactr-1 gene, indicating that huperzine has an anti-metastatic effect on human pancreatic cancer cells. Here, VEGFA is linked to familial pancreatic carcinoma.