RHO and breast cancer: In the same way, alterations in the actin cyto-skeleton and decreased expression of the adhesion molecules E-cadherin and β-catenin in the breast cancer line MCF-7 cells at a low dose of this pesticide resulted in the loss of E-cadherin accompanied by an increase in the expression of Rho and Rac1 GTPases, which promote cytoskeleton rearrangements, migration, and invasion [48].