In a multicentre retrospective study, Ammirati et al. described a population of patients with acute myocarditis and their genetic data, showing that those with a family history of myocarditis, non-sustained VAs, and a septal/RL-LGE were more likely to carry a desmosomal gene variant (mostly DSP) (68% and 85% for RL and septal LGE, respectively) [47]. This evidence concerns the gene DSP and myocarditis.