FIS1 and diabetes mellitus: Furthermore, EAT showed an increased expression of OPA1 EAT in the NDM (p = 0.017), DM (p = 0.013), and NCAD group (p = 0.002), while FIS1 was upregulated in the NDM (p = 0.012), DM (p = 0.040), and NCAD group (p ≤ 0.001).