FMO5 and atherosclerosis: Additionally, two variants of the CYBA gene, i.e., NM_000101.4 (CYBA):c.214T>C p.His72Tyr (rs4673) and CYBA c.-932A>G (rs9932581), are associated with heightened oxidative stress and an increased risk of atherosclerosis as CYBA encodes the alpha subunit of cytochrome b(-245), which is a component of the NADPH oxidase (NOX) complex, required for ROS generation [102].