UCP1 and obesity due to melanocortin 4 receptor deficiency: The study by Demet et al. [129] demonstrated that liposomal encapsulation enhances the stability and bioavailability of berberine, highlighting its potential, particularly in its liposomal form, to induce browning (via uncoupling protein 1, UCP1) and modulate lipid metabolism in adipocytes, laying the foundation for novel anti-obesity strategies.