VDR and colorectal cancer: Studies using different cancer cells have demonstrated the induction of miRNAs by vitamin D. The first miRNA targeting the VDR was identified by Mohri et al. [78], who showed that miR-125b directly regulates the expression of the VDR gene in the breast cancer cell line MCF-7 and that its overexpression can abrogate the antiproliferative effect of vitamin D. Furthermore, miR-27b is a regulator of VDR gene expression in melanoma, colorectal cancer and pancreatic cancer cell lines [81,82].