CDX2 and cancer: Due to the involvement of vitamin D in cell differentiation and death, as well as in limiting the number of cell divisions, the polymorphisms, viz., TaqI (rs731236, C > T), BsmI (rs1544410, A > G), FokI (rs2228570, T > C), ApaI (rs7975232, A > T) and Cdx2 (rs11568820, A > G) may be important in the origin of many diseases: cancer, metabolic diseases including obesity, cardiovascular, neurodegenerative and autoimmune diseases.