Key Targets for Diabetic Nephropathy Intervention: The top 10 targets, ranked by Degree value, were AKT1, EGFR, HSP90AA1, SRC, CASP3, GRB2, ESR1, HSP90AB1, HRAS, and GSK3B (Figure 3B). The gene discussed is EGFR; the disease is diabetic kidney disease.