Notably, seven validated SNVs were detected in MAP4K2, SIN3B, TAOK2, KDR, TP53, MYC, and NLRC4, and the subsequent analysis of archived material indicated that TP53, TAOK2, and MAP4K2 alterations were present in the primary tumor, whereas KDR, MYC, SIN3B, and NLRC4 arose only in metastatic lesions [53]. This evidence concerns the gene SIN3B and neoplasm.