In particular, the testes from CIS + RSV-treated rats presented a high expression of antioxidant enzymes, including SOD, CAT, and GPx, and GSH, together with a down-regulation of those of cleaved caspase 3, BAX, P53, pAKT/pbad, cleaved calpain 1/caspase 12, p-ERK1/2, and p-SAPK/p-JNK [181]. The gene discussed is SOD1; the disease is in situ carcinoma.