In particular, when CIS was used in combination with RSV (1 mg/kg/day for 4 weeks), it not only determined an improvement in spermatic parameters such as sperm motility and concentration, but also reduced OS as evidenced by the increase in tissue expression levels of GSH, GPx, GST, SOD, and CAT and by the reduction in those of LP and NO [216]. The gene discussed is CAT; the disease is in situ carcinoma.