EGR1 and diabetes mellitus: Among them, EIF4EBP1, which is upregulated in the retina of diabetic mice [71] and contributes to diabetes-induced vascular dysfunction [72], ALKBH5, which is upregulated in AMD and associated with increased VEGF secretion in RPEs [73], and early growth response 1 (EGR1) transcription factor, which promotes neovascularization in ROP models [74], were significantly induced in ARPE-19 cells exposed to Roxadustat.