SERPINE1 and age-related macular degeneration: We showed a significant increase in Roxadustat-treated ARPE-19 cells whose gene expression pattern overlaps with several angiogenic genes involved in DR and AMD, such as ANGPTL4 [60], VEGF [22,23], ANG [52], ADM [61], RORA [62], SERPINE1 [63], ITGB3 [64], ADAMTS1 [65], CXCR4 [66], and LOXL2 [67].