Methyltransferase-like protein 7B (METTL7B), a member of the methyltransferase-like family containing the methyltransferase structural domain, inhibits the expression of USP38 through m6A-dependent mRNA degradation, leading to increased ubiquitination of HDAC3, which maintains histone lactylation at a later stage to improve cardiac remodeling and thus prevent heart failure [91]. The gene discussed is HDAC3; the disease is heart failure.