HDAC3 deacetylates DNA methyltransferase 1 (DNMT1) to inhibit ubiquitination-mediated degradation, which promotes the expression of DNMT1, which inhibits the expression of SHP-1 by methylation of the promoter region, thereby leading to heart failure induced by cardiomyocyte hypertrophy [92]. The gene discussed is HDAC3; the disease is heart failure.