AGT and cardiac hypertrophy: Calmodulin-dependent protein kinase II (CaMKII) is a direct downstream target of β-adrenergic [42] as well as Gαq signaling [43] (endothelin and angiotensin II), and mediates cardiomyocyte death [44], cardiac hypertrophy [45], as well as fibrosis [46] driven by neurohormone overactivity.