A study identified Comp 5 (small-molecule compound F0911–7667) as an effective and selective activator of SIRT1, which induces autophagic cell death in glioblastoma cells via the AMPK-mTOR-ULK (AMP-activated protein kinase–mammalian target of rapamycin–Unc-51-like kinase) complex pathway [48]. This evidence concerns the gene SIRT1 and glioblastoma.