SIRT7 regulates IDH1 transcription through its interaction with SREBP1 (Sterol Regulatory Element-binding Protein 1), influencing the production of IDH1 (Isocitrate Dehydrogenase (NADP(+)) 1) in glioma cells and their metabolic reprogramming [148]. The gene discussed is SREBF1; the disease is central nervous system cancer.