Notably, SIRT1 expression is higher in aggressive subtypes of medulloblastoma (large cell/anaplastic—79.07% and classic medulloblastomas—60.29%) compared with less aggressive ones (nodular/desmoplastic subtype—22.22%), indicating a potential link between SIRT1 and tumor aggressiveness [56]. The gene discussed is SIRT1; the disease is medulloblastoma.