In turn, ESHE decreased IL-1β, IL-6, TNF-α, MMP-2, MMP-9, KDR, HIF1a and RELA mRNA expression, IL-1β protein expression and MMP-2 and MMP-9 activity in CCD841CoN cells, demonstrating that it may mitigate inflammation in the colon observed in UC and CD, and may exert a chemopreventive effect against the development of CRC. Here, KDR is linked to colorectal carcinoma.