L1CAM and Familial prostate cancer: In human prostate cancer PC3 cells, L1CAM knock-down leads to a decrease in the expression of bcl-2 interacting protein 3 and different antioxidant enzymes that are important for ROS homeostasis including catalase, GPX1, GPX2, GPX4, GRP78, NOX5, SOD1, SOD2, and BIRC5 [64].