For example, in an animal model of lipopolysaccharide (LPS)-induced ALI, the protein expression level of HIF-1α in lung tissues was significantly elevated within a short period of time [64], and its transcriptional activity was correspondingly increased, correlating with the degree of hypoxia, which fully confirms the key driving role of hypoxia in the activation of HIF-1. Here, HIF1A is linked to acute respiratory distress syndrome.