In addition to SS, ETB has also been shown to be modulated by other stimuli, including perfusion pressure, where increased pressure leads to upregulation of ETB mRNA [69,70], as well as cytokines, growth factors, including TNF-α and fibroblast growth factor, and low-density lipoproteins [71,72]. The gene discussed is EDNRB; the disease is synovial sarcoma.