TLR7 and kidney disorder: Cosgrove et al. showed that TLR7 deficiency in CD19+ B cells of C57BL/6 mice yielded mild suppression of proteinuria, whereas B cell-intrinsic TLR7 expression enhanced renal disease and anti-RNA, but not anti-Sm Ab or anti-nucleosome autoantibodies in TLR-9-deficient MRL/lpr mice [28].