In platelets isolated from ITP, elevated NLRP3 and IL-1β correlates with reduced antioxidant capacity and the exposure of platelets to H2O2 further amplifies the expression of these pyroptotic markers, indicating a direct link between inflammasome activation and pyroptosis-induced platelet death [34]. This evidence concerns the gene NLRP3 and autoimmune thrombocytopenic purpura.