CD44 and gastric cancer: For instance, the expression of miR-7-5p is diminished in CD44+ gastric cancer cell lines, which impedes the function of Smo (a pivotal protein in the Hedgehog signaling pathway) and Hes1 (a downstream target gene of the Notch signaling pathway) by targeting these two signaling pathways, consequently decreasing the colony formation and invasive capacity of GCSCs [85].