In hepatocellular carcinoma, miR-486-5p diminishes Sirt1 expression by binding to its 3′UTR, thereby inhibiting the expression of stem cell-related genes (e.g., SOX2, OCT4, and CD13) and ultimately suppressing the self-renewal capacity of hepatocellular carcinoma cancer stem cells (CSCs) [55]. The gene discussed is POU5F1; the disease is cancer.