SHH and cancer: Another pivotal regulator is miR-137, which frequently functions as a suppressor of stemness, inhibiting stemness characteristics such as self-renewal and metastasis of cancer stem cells (CSCs) by targeting genes including DCLK1, SOX2, NANOG, and FUNDC1, as well as the Wnt and SHH signaling pathways across various CSCs, including those in colon [125], pancreatic [126], glioblastoma [127] and breast [128] cancers.