3xTg-AD is a triple-transgenic mouse that expresses the Swedish APP mutation (KM670/671NL), presenilin 1 (PSEN1) M146V mutation, and the microtubule-associated protein tau (MAPT) P301L mutation, and it develops both Aβ plaques and neurofibrillary tangles (NFTs) [42]. Here, APP is linked to Alzheimer disease.