Notably, biochemical evidence of the disruption of glycogen synthase kinase 3-beta (GSK3B) homeostasis has been reported in platelets [73], where the proportion between phospho-GSK3B and total GSK3B (GSK3B ratio) is significantly reduced in patients with MCI and AD compared with controls (with a positive correlation with memory test results). Here, GSK3B is linked to Alzheimer disease.