SLC2A1 and obesity due to melanocortin 4 receptor deficiency: To further clarify the content of ANLS, researchers revealed recently that the GLUT1 on the membrane of astrocytes is a potential genetic target for energetic diseases such as obesity or neurodegeneration since partial reduction of GLUT1 of astrocytes can significantly enhance brain glucose metabolism and relieve HFD-induced glucose resistance [43,44].