IL2 and cancer: Since immune cells in the TME play a critical role in cancer progression and response to treatments, we investigated the association of GS levels with several immune response-related pathways including inflammatory response, interferon (IFN)-α and IFN-γ responses, allograft rejection, IL2/STAT5 signaling, IL6/JAK/STAT3 signaling, coagulation cascade, and complement signaling.