At the Verspeeten Family Cancer Centre, an academic hospital in London, Ontario, the implementation of NP-led clinics for adjuvant ET, established through the Participatory, Evidence-based, Patient-focused Process for Advanced Practice Nursing (PEPPA) framework from Cancer Care Ontario, provided a foundation for a new NP-led clinic to manage adjuvant therapies, including CDK4/6 inhibitor therapy [13]. The gene discussed is CDK4; the disease is cancer.