It has been proven that the PDL1 protein is highly expressed in solid cancers, such as non-small-cell lung cancer, gastric cancer, adrenocortical carcinoma (ACC), small-cell carcinoma of the esophagus, and inflammatory myofibroblastic tumor [17,18,19,20,21]. The gene discussed is CD274; the disease is esophageal small cell neuroendocrine carcinoma.