HTR2B and colorectal neoplasm: A recent animal study demonstrated that 5-HT2B is highly expressed in colorectal tumor tissues and that both the pharmacological inhibition and genetic knockdown of 5-HT2B hindered the migration of CRC cells and disrupted the epithelial–mesenchymal transition process, indicating a regulatory role of 5-HT2B signaling on CRC metastasis [156].