In accurate DSS-induced and chronic IL-10 deficient colitis models, the pharmacological blockade or genetic ablation of 5-HT7 resulted in an increased severity of colitis, whereas receptor stimulation showed an anti-inflammatory effect [161], although another study contradictorily reported that the inhibition of 5-HT7 receptor signaling ameliorated both DSS- and TNBS-induced colitis [162]. The gene discussed is IL10; the disease is colitis.