Based on our experience, we observed that marked and sudden weight fluctuations with a yo-yo effect should be avoided both for the potential negative effects on adipose tissue and metabolic consequences, including hyperinsulinemia and elevated basal insulin secretion [53,54], but also because the goal of treating lipedema is to obtain positive results that can be maintained over time given the chronicity of the disease. This evidence concerns the gene INS and hyperinsulinism.