Among further unexpected reactions, CLP occurred during treatment with dupilumab for AD in a 60-year-old woman with a previous history of allergy and alopecia areata after the failure of cyclosporine, which was primarily resulting from the upregulation of Th1 chemokines including IFN-γ, TNF, IL-1α, IL-6, and IL-8 [71]. Here, TNF is linked to Alzheimer disease.