Notably, the VDR rs731236 T-allele was associated with higher 25(OH)D concentrations and a lower BMI, suggesting a dual protective role, while the CYP2R1 rs10741657 A-allele was linked to both reduced vitamin D status and increased adiposity [41,42]), with potential long-term consequences for metabolic health, including an increased risk of conditions such as type 2 diabetes [43]. This evidence concerns the gene CYP2R1 and type 2 diabetes mellitus.