To test this hypothesis, Ang II was used to treat THP-1-like macrophages for 24 h, then culture media was used as the conditioned media and applied at 50% on MCF-7 and MDA-MB-231 breast cancer cell lines at different time points to investigate how Ang II affects the interaction between TAMs and the breast cancer microenvironment. The gene discussed is AGT; the disease is breast cancer.