TIMP1 and neoplasm: Thus, RAS signaling activation through AT1R fosters the activation of transcription factors (NF-κB, STAT 3) that induce various tumor growth and progression factors (IL-6, IL-8, MCP-1, macrophage colony-stimulating factor (M-CSF), VEGF, tissue inhibitor of metalloproteinase 1 (TIMP1)) integral to the TME [51].