A number of genetic risk factors have been described, including hereditary breast and ovarian cancer syndrome (BRAC1, BRCA 2, and PALB2 genes), Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM genes), familial adenomatous polyposis (APC gene), Peutz-Jeghers syndrome (STK11, LKB1 genes), hereditary pancreatitis (PRSS1, SPINK 1), and cystic fibrosis (CFTR gene) among others, which increase the incidence of PDAC by between 2 and 132 times [8]. This evidence concerns the gene STK11 and Hereditary breast and ovarian cancer syndrome.