Virus infections in cell culture often trigger interferon (IFN) responses mediated by IFN type I (IFN-α, IFN-β, and others) and IFN type III (IFN-λ); IFN type II (IFN-γ) is usually not a factor that limits virus replication in cell culture as it is predominantly produced by immune cells (reviewed in reference 5). The gene discussed is IFNA1; the disease is viral infectious disease.