GNAT3 and periodontitis: Activating Tas2r105 with denatonium benzoate in wild‐type mice was shown to upregulate antimicrobial β‐defensin‐3, reducing bone loss and bacterial load—an effect absent in Gnat3−/− mice, confirming the pathway's role, and thus the importance of Tas2r105 activation in regards to periodontitis [127].