TP53 and breast carcinoma: Moreover, breast cancer cells undergo time‐dependent apoptosis when exposed to harmine, with real‐time PCR results indicating that its apoptotic induction in MCF‐7 cells relies on activating p53 gene expression [76] Colchicine inhibits HPV E6/E7, causing p53‐dependent intrinsic apoptosis, which has antiproliferative effects on human cervical cancer cell lines positive for HPV 16/18 in vitro [77].