The elevated plasma level of SNAP‐25 in AD (0.81 pg/mL vs. 0.6 pg/mL) had a significant correlation with MMSE (β = −6.69, P = 0.001), cortical atrophy (β = −0.05, P = 0.009), and amyloid centiloid (P = 0.016, rho = 0.48).79, 80. The gene discussed is SNAP25; the disease is Alzheimer disease.