Besides, the DALs observed between the HBE and HFD control groups were predominantly enriched in various lipid metabolic pathways, including choline metabolism in cancer, cholesterol metabolism, fat digestion and absorption, lipid and atherosclerosis, retrograde endocannabinoid signaling, insulin resistance, vitamin digestion and absorption, and arachidonic acid metabolism pathway. The gene discussed is INS; the disease is atherosclerosis.