APOC3 and diabetes mellitus: Using differentially expressed genes (DEGs) with adjusted p-values <0.05 and a Z-score cutoff of 2 in both models of diabetes compared to their non-diabetic controls and regulation in the opposite direction in APOC3 ASO-treated mice vs cASO-treated diabetic littermates revealed that diabetes enriched 19 pathways in the resident macrophage cluster over their non-diabetic controls.