APOC3 and diabetes mellitus: The top enriched pathway in diabetic mice strongly prevented by APOC3 silencing was neutrophil degranulation, but a pathway related to lipoprotein metabolism, driven by lipid-related genes including Abca1, Abcg1, Apoe, and Soat1 was also enriched by diabetes and prevented by APOC3 silencing (Fig. 3e).