To gain a deeper understanding of how hepatic APOC3 silencing affects the lesioned artery in diabetes, single-cell RNA-sequencing (scRNA-seq) was performed on aortic arches from the two mouse models of diabetes and diabetic mice treated with the APOC3 GalNAc ASO (Fig. 3a-c, Extended Data Fig. 7a-f; Supplemental Excel 1–2). The gene discussed is APOC3; the disease is diabetes mellitus.